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KMID : 0941820130230040316
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Korean Journal of Clinical Pharmacy
2013 Volume.23 No. 4 p.316 ~ p.321
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Drug-drug Interactions between Atorvastatin and Telmisartan
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Park Jin-Hyun
Noh Keum-Han
Lim Mi-Sun
Kang Won-Ku
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Abstract
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Purpose: Atorvastatin, a HMG-CoA reductase inhibitor is widely prescribed in hyperlipidemic patients and telmisartan, an angiotensin receptor blocker is frequently used in the treatment of hypertension. Both drugs are substrates of organic anion transporting polypeptide (OATP) expressed in basolateral membrane in the liver, and undergo high first pass metabolism. Therefore, OATP-mediated hepatic uptake is important for disposition and metabolism of these drugs. The present study was designed to investigate the pharmacokinetic interactions between atorvastatin and telmisartan in rats.
Method: Young adult SD rats were divided into three groups (n=6, each) and atorvastatin (10 mg/kg) and telmisartan (4 mg/kg) were orally given alone and together. Heparinized blood was serially taken and plasma concentrations of both drugs were measured using HPLC-MS/MS. Pharmacokinetic parameters of two drugs were calculated.
Results: No significant pharmacokinetic change was found except a delay of time to peak of telmisartan when administered with atorvastatin. Each drug at the present dosage seemed to be insufficient to alter the pharmacokinetic parameters of its counterpart drug.
Conclusion: Conclusively, co-administration of atorvastatin and telmisartan may lead to negligible clinical consequences.
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KEYWORD
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Atorvastatin, Telmisartan, Pharmacokinetics, OATP, Rats
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